Molecular, Cell & Cancer Biology Adjunct Faculty

Macromolecular Delivery Systems for Cancer Therapeutics

Research in my lab is focused on the design of safe, biocompatible, injectable polymers for delivery of chemotherapeutics and genes. We are interested in prodrug design and synthesis for the masking of chemotherapeutic toxicity prior to delivery, and solubilization of difficult-to-administer drugs in aqueous soluble and stable environments. Finally, we are developing drug delivery platforms that are amenable to two or more drugs for tandem delivery and sequential release.

Metal Homeostasis in Cancer: Disease Mechanisms and Therapeutic Strategies

Research in my lab focuses on the mechanisms by which dysregulation of metal transport and homeostasis, particularly iron and copper, contributes to cancer development and progression. We investigate how genetic, nutritional, and environmental factors influence iron and copper metabolism and toxicity using pharmacological and toxicological approaches. Our work also develops therapeutic strategies, including small molecules and nanoparticle-based delivery systems, to target metal-dependent pathways in cancer and related diseases.

Mitochondrial Biology in Cancer: Therapeutic Strategies for Muscle Atrophy and Cardiotoxicity

Our lab focuses on elucidating the molecular, functional, and structural regulation of mitochondria in cardiac and skeletal muscle physiology and pathology. We investigate the mechanisms underlying mitochondrial dysfunction and explore potential therapeutic strategies, including small molecules, pharmacological agents, and exercise, for mitochondrial disorders associated with heart disease, muscle atrophy, and other conditions. In particular, we seek to identify preventive and restorative approaches to mitigate chemotherapy-induced cardiotoxicity and muscle weakness associated with cancer cachexia, with an emphasis on mitochondrial dynamics and quality control systems.