Metabolic State Control in Tissues

Tissues must dynamically transition between energy-storing and energy-expending states to maintain systemic metabolic balance.

We investigate how these metabolic states are established, maintained, and remodeled within and across tissues, with a particular focus on adipose biology and mitochondrial function. Our work seeks to understand how cellular heterogeneity, tissue architecture, and environmental inputs shape metabolic flexibility, and how disruptions in these processes contribute to impaired energy balance.

Key Questions

What defines anabolic vs catabolic states?

How is metabolic flexibility regulated?

How does tissue organization influence metabolism?

Experimental Systems

Adipose tissue (BAT, beige, WAT)

In vivo stable isotope tracing

Spatial + single-cell approaches