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Kara Smith, MD, publication report from PubMed

  • Induction of human pruriceptors from pluripotent stem cells via transcription factors

    Thursday, July 09, 2026
    Author(s): Hisato Iriki,Ruiqi Hu,Xu Li,Erdene Baljinnyam,Carina Habich,Ichiro Imanishi,Loan N Miller,Kavya Chegireddy,Laraib Iqbal Malik,Daniel Yassky,Raphael Kübler,Aaron Ver Heul,Kathleen M Smith,Peter Reinhardt,Eric R Goedken,Brian S Kim,Samuele G Marro
    Source: Stem cell reports
    Pruriception is crucial for defense against external stimuli but can lead to chronic pruritus, a debilitating condition affecting millions worldwide. Our understanding of the cellular and molecular mechanisms behind the sensation of itch has been hindered by the lack of functional human models. Here, we address this limitation by developing a protocol to generate induced pruriceptors (iPruriceptors) from human-induced pluripotent stem cells (iPSCs). We compared two differentiation approaches: a...

  • NIH-funded Institutional Training Programs in Colleges and Schools of Pharmacy

    Saturday, July 04, 2026
    Author(s): Kathleen M Giacomini,Lawrence Lin,Christopher K Surratt,Krystal L Edwards,Susan Davis,Kelly M Smith,Kayla R Stover,William P Petros,Sam Calabrese,Jennifer D Robinson,Philip D Hall
    Source: American journal of pharmaceutical education
    Unlike nursing and dentistry, pharmacy lacks a dedicated institute within the National Institutes of Health (NIH) to support its research and training needs, despite having many NIH-funded researchers within Colleges and Schools of Pharmacy (C/SOP). As a result, C/SOPs must compete across all NIH institutes for institutional (T-series) as well as individual (F-series) training grants. In 2024, the Council of Deans of the American Association of Colleges of Pharmacy (AACP) tasked a working group...

  • Study protocol: targeted delivery of interleukin-12 in combination with hepatic artery infusion pump therapy for patients with adrenocortical carcinoma liver metastases

    Saturday, June 27, 2026
    Author(s): Lindsay R Friedman,Emily C Smith,A Leila Sarvestani,Alyssa V Eade,Jason Ho,Tracey Pu,Carolina Larrain,Cathleen E Hannah,Tamika Magee,Kathleen M Smith,Audra A Satterwhite,Sophia Xiao,Justine F Burke,Surajit Sinha,Priyanka P Desai,Kirsten Remmert,Michael J Cavnar,James L Gulley,Jeffrey Schlom,Jaydira Del Rivero,Jonathan M Hernandez
    Source: BMC cancer
    BACKGROUND: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy often detected at an advanced stage with limited effective treatment options beyond first-line chemotherapy. The liver is a common site of metastasis, and patients frequently present with substantial hepatic disease burden that precludes complete resection. Locoregional therapies, including hepatic artery infusion pump (HAIP) delivery of floxuridine, have not been thoroughly evaluated for treatment of ACC liver...

  • Clinical Characteristics of Pediatric Patients With Cervical Collar-Related Pressure Injuries

    Thursday, June 25, 2026
    Author(s): Anastasia M Kahan,Natalya E McNamara,Stephanie E Iantorno,Karch M Smith,Kezlyn E Larsen,Robert A Swendiman,Katie W Russell
    Source: Journal of trauma nursing : the official journal of the Society of Trauma Nurses
    CONCLUSION: Pediatric patients with CCRPI are characterized by those requiring PICU admission for acute illness, mechanical ventilation, sedation, vasopressor support, and intracranial monitoring. The majority of pediatric patients with CCRPI were placed in cervical collars prophylactically for an extended time. This study highlights that cervical collars are a medical intervention that necessitates a thoughtful risk-benefit analysis.

  • Dihydropyridine Calcium Channel Blocker-induced Prescribing Cascades: Signal Detection using High-throughput Sequence Symmetry Analysis

    Thursday, June 04, 2026
    Author(s): Priyanka J Kulkarni,Asinamai Ndai,Shailina Keshwani,Kayla M Smith,Jaeyoung Choi,Michael Luvera,Julia Hunter,Shannon Wright,Julia Hetzel,Carl J Pepine,Stephan Schmidt,Earl J Morris,Steven M Smith
    Source: medRxiv : the preprint server for health sciences
    CONCLUSION: Potential PCs identified in this Medicare cohort reflected known and underrecognized adverse effects of DHP-CCBs. Further studies are needed to evaluate the clinical consequences of these PCs.

  • A Review of Artificial Intelligence Across the Facial Esthetic Surgical Continuum: Education, Planning, Intraoperative Use, and Postoperative Outcomes

    Friday, May 15, 2026
    Author(s): Kierstyn M Smith,Adrian Santana,Seth R Thaller
    Source: The Journal of craniofacial surgery
    Artificial intelligence (AI) is increasingly used in facial aesthetic surgery. This specialty is well-positioned to benefit from its ability to analyze large visual data sets and provide more objective outcome measurements. The authors' review will focus on current AI applications across various aspects of facial aesthetic procedures. Primarily, the authors will focus on their impact on patient-centered care. A comprehensive review of peer-reviewed literature from 2021 to 2026 identified 44...

  • Relationships between physically effective undegraded neutral detergent fiber and rumen fermentable starch in diets for lactating Holstein dairy cows

    Monday, May 11, 2026
    Author(s): K M Smith,A Obata,S Y Morrison,J W Darrah,H M Dann,C S Ballard,M D Miller,R J Grant
    Source: Journal of dairy science
    We assessed the effect of rumen fermentable starch (RFS; 7-h in vitro starch digestibility) in diets that contained low or moderate physically effective undegraded NDF after 240-h of in vitro fermentation (peuNDF240) on DMI, milk yield and composition, chewing behavior, ruminal function, and apparent total-tract nutrient digestibility. Sixteen lactating Holstein cows (8 ruminally cannulated) averaging 85 ± 15 (SD) DIM were enrolled in a replicated 4 × 4 Latin Square design (28-d periods) with a...

  • Strategies to Address Communication Vulnerability in Adult Intensive Care Units Through Practice, Environment, and Policy Modifications

    Monday, April 27, 2026
    Author(s): Praisy Rampogu,Laura Istanboulian,Amy Freeman-Sanderson,Kelly M Smith,Karen Soldatić
    Source: Journal of nursing care quality
    No abstract

  • Return to golf after shoulder arthroplasty: an American Shoulder and Elbow Surgeons multicenter study predicting performance after reverse total shoulder arthroplasty and anatomic total shoulder arthroplasty

    Sunday, April 12, 2026
    Author(s): ASES Multicenter Research Group
    Source: Journal of shoulder and elbow surgery
    BACKGROUND: Return to sport (RTS), particularly golf, and athletic performance following reverse shoulder arthroplasty (rTSA) and anatomic shoulder arthroplasty (aTSA) remain largely understudied. Moreover, limited data exist on characteristics that predict successful RTS. This study aimed to evaluate return to golf after shoulder arthroplasty, as well as identify patient factors associated with optimal return to play.

  • Aerodynamic and Acoustic Characteristics of Nasal Airflow in Parkinson's Disease

    Wednesday, April 08, 2026
    Author(s): Jenny Vojtech,Talia S Mittelman,Kara M Smith,Defne Abur,Cara E Stepp
    Source: Journal of speech, language, and hearing research : JSLHR
    CONCLUSIONS: Velopharyngeal dysfunction in PD was more pronounced during rapid motor sequences (stop consonant bursts) than vowel production and showed dynamic motor deterioration under increasing vocal intensities. The intensity-airflow relationship observed in PD suggests compromised velopharyngeal closure during higher vocal demands. Measures of velopharyngeal dysfunction may be useful markers of axial motor symptom severity, which has a large impact on quality of life and prognosis in people...

  • Tumor-Targeted IL-12 (PDS01ADC) with Hepatic Artery Infusion Pump Therapy for Colorectal Liver Metastases: Interim Analysis of a Non-randomized Phase II Trial

    Monday, April 06, 2026
    Author(s): Alyssa V Eade,Emily C Smith,Cecilia Monge,Cathleen E Hannah,Nebojsa Skorupan,Donna M Hrones,Carolina Celades,Meghali Goswami,Hana Bagheri,Kathleen M Smith,Ashley J Rainey,Lindsay R Friedman,Carolina Larrain,Tracey Pu,Surajit Sinha,Priyanka P Desai,Kirsten Remmer,Audra A Satterwhite,Stacy R Joyce,Aaron J Dinerman,Bradford J Wood,Michael T Kassin,Ifechi N Ukeh,Andrew M Blakely,Jeremy L Davis,David E Kleiner,Wiem Lassoued,Sofia R Gameiro,Renee N Donahue,James L Gulley,Jeffrey Schlom,Jonathan M Hernandez
    Source: JCO oncology advances
    CONCLUSION: Addition of PDS01ADC is not detrimental to HAIP therapy and is associated with both systemic and intratumoral immune modulation. Initial results warrant continuation to full enrollment for further evaluation of clinical and scientific endpoints.

  • Autoimmune Causes of Epilepsy

    Friday, April 03, 2026
    Author(s): Julie B Guerin,Brian J Burkett,Kelsey M Smith,Divyanshu Dubey,Lily C Wong-Kisiel,V Michelle Silvera
    Source: Neuroimaging clinics of North America
    This article reviews the clinical, imaging, and pathologic features of autoimmune encephalitis, emphasizing the diagnostic and therapeutic relevance of antibody class and target location. Surface antibody syndromes, such as anti-NMDAR and antileucine-rich glioma-inactivated 1 encephalitis, typically present with seizures, and psychiatric symptoms, and have good immunotherapy response. Intracellular antibodies, such as anti-Hu or Ma2, are often paraneoplastic and associated with irreversible...

  • Return to sport after shoulder arthroplasty: an ASES multicenter analysis of sport-specific predictors of performance in reverse shoulder arthroplasty and total shoulder arthroplasty

    Friday, April 03, 2026
    Author(s): Jason Corban,Jacob M Kirsch,Adam Bowler,Evan A Glass,Declan R Diestel,Regan P Arnold,Miranda McDonald-Stahl,Calista S Stevens,Richard Puzzitiello,Michael A Moverman,Kiet Le,Warren Dunn,Andrew Jawa,ASES Multicenter Research Group
    Source: Journal of shoulder and elbow surgery
    CONCLUSION: Return to sport following shoulder arthroplasty is high, with most patients reporting maintained or improved performance. In patients with GHOA, rTSA was associated with higher rates of improved or stable sport performance and greater satisfaction compared to aTSA.

  • Effect of Single-Stage Posterior Vomerine Ostectomy/Premaxillary Setback on Facial Growth in Bilateral Cleft Lip and Protuberant Premaxilla

    Monday, March 30, 2026
    Author(s): Usama S Hamdan,Lucille Ridgell,Jose A Garcia-Garcia,Dhruv Ahuja,Kaitlin M Smith,Lizbeth Roman,Beyhan Annan,Giuliana Roggiero,Wassim Najjar,James Liau,Puneet Batra
    Source: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
    ObjectiveTo evaluate the impact of single-stage posterior vomerine ostectomy with premaxillary setback (PVPS) on craniofacial development in children with bilateral cleft lip and palate (BCLP) and a protuberant premaxilla.DesignRetrospective pilot study.SettingResource-limited outreach setting.Patients, ParticipantsFifty-two children were included: 22 with BCLP who underwent PVPS before 8 years of age and 30 age-matched non-cleft controls.InterventionsSingle-stage PVPS with bilateral...

  • CD64 binding potential does not translate into enhanced therapeutic efficacy for anti-IL-23 antibodies under physiologically relevant conditions

    Saturday, March 28, 2026
    Author(s): Joel F Cohen-Solal,Calvin S Pohl,Sheila M Cummings,Jeremy P Gygi,Zhaleh Safikhani,Brigitte Bartocha,Christopher D Buckley,Yongli Dong,Killian Eyerich,Samuel D Karsen,Grace R Lynch,Michael Macoritto,Pierre A Morisset,Ornella D Nelson,Timothy Radstake,Florian Rieder,Jocelyn Rivas,John P Savaryn,Kathleen M Smith,Madison Stulir,Carmin Szynal,Casey Tylek,Geertruida M Veldman,Laura G Wasserman,Susan Westmoreland,Neha Chaudhary,Matthew M Staron
    Source: Molecular medicine (Cambridge, Mass.)
    BACKGROUND: Interleukin (IL)-23 neutralizing antibodies are clinically efficacious but differ in the functionality of their Fc portion. Guselkumab (GUS) and ustekinumab (UST) have a wild-type (WT) Fc portion, permitting native binding to Fc gamma receptors (FcγRs), while risankizumab (RZB) lacks FcγR binding due to the L234A to L235A (LALA) mutation. Recently, GUS was reported to neutralize IL-23 more effectively than RZB in vitro, owing to GUS-mediated binding of FcγRI (CD64) on macrophages....

  • Population-Based Epidemiology of Autoimmune Seizures and Epilepsies

    Wednesday, March 25, 2026
    Author(s): Smathorn Thakolwiboon,Kathryne N Wood,Andrea Stabile,Naveen Paramasivan,Jeffrey W Britton,Kelsey M Smith,Surendra Dasari,Michelle F Devine,Andrew McKeon,Anastasia Zekeridou,Eoin P Flanagan,Sean J Pittock,Divyanshu Dubey
    Source: Annals of neurology
    OBJECTIVE: To estimate the prevalence, incidence, and disease burden of autoimmune seizures and epilepsies in Olmsted County.

  • Combined Root and Body Lateral Meniscus Tears in the Adolescent Population: An Underrecognized and Underreported Tear Pattern

    Wednesday, March 18, 2026
    Author(s): Karch M Smith,James D Bomar,Andrew T Pennock
    Source: The American journal of sports medicine
    CONCLUSION: CRAB tears are underdiagnosed preoperatively and are relatively common injury patterns, especially in the setting of adolescent patients undergoing primary ACL reconstruction with higher BMI and nonclassic bone bruising. If a radial tear of the meniscal body is identified arthroscopically, the surgeon should carefully evaluate the posterior root of the meniscus to ensure there is not a second tear that could otherwise be potentially missed.

  • Regioselective Halogenation of BOPPY Fluorophores and Subsequent Diversification via Cross-Coupling and Aromatic Nucleophilic Substitution Strategies

    Tuesday, March 10, 2026
    Author(s): Sebastian O Oloo,Petia Bobadova-Parvanova,Alexis A Lueders,Mina Kim,Frank R Fronczek,Kevin M Smith,Maria da Graça H Vicente
    Source: The Journal of organic chemistry
    The regioselective mono- and tribromination of a BOPPY dye followed by its reactivity under Pd-catalyzed cross-coupling and nucleophilic substitution reactions are reported. The brominated BOPPYs undergo Pd(0)-catalyzed cross-couplings with a variety of boronic acids and organotin reagents to give the corresponding products in good-to-excellent yields. Nucleophilic aromatic substitutions occur both on the mono- and tribromo-BOPPYs. The reactivity order of the latter is C3-Br C1-Br C2-Br,...

  • Return to weightlifting after shoulder arthroplasty: an ASES multicenter study predicting performance after reverse shoulder arthroplasty and anatomic shoulder arthroplasty

    Saturday, February 28, 2026
    Author(s): Declan R Diestel,Suleiman Sudah,Nick Veale,Regan Arnold,Jason Corban,Jacob M Kirsch,Adam Bowler,Evan A Glass,Shannon E Gray,Miranda McDonald-Stahl,Calista S Stevens,Richard Puzzitiello,Michael A Moverman,Kiet Le,Warren Dunn,Andrew Jawa,ASES Multicenter Research Group
    Source: Journal of shoulder and elbow surgery
    CONCLUSION: Most patients resume weightlifting after shoulder arthroplasty, often maintaining or improving performance. Although outcomes are comparable by arthroplasty type, rTSA may afford better deltoid function and increased participation frequency. Additionally, pre-operative diagnosis appears to influence enjoyment and engagement following rTSA, despite similar improvements across specific exercises. These findings highlight the complex nature of recovery and the value of personalized...

  • Probing the Feasibility of Single-Cell Fixed RNA Sequencing from FFPE Tissue

    Friday, February 13, 2026
    Author(s): Xiaochen Liu,Katherine Naughton,Samuel D Karsen,Patricia Bentley,Lori Duggan,Neha Chaudhary,Kathleen M Smith,Lucy Phillips,Dan Chang,Naim A Mahi
    Source: International journal of molecular sciences
    Single-cell RNA sequencing (scRNA-seq) provides a comprehensive understanding of cellular complexity; however, its requirement for fresh or frozen samples limits its flexibility. To overcome this limitation to effectively leverage clinical samples, Chromium Fixed RNA Profiling on formalin-fixed paraffin-embedded (FFPE) tissue blocks (scFFPE-seq) was developed to perform single-nucleus RNA sequencing from nuclei isolated from FFPE. In this study, we utilized fresh tissue samples from colon,...