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Andrei Korostelev, PhD

Professor, RNA Therapeutics Institute

Website

Research Focus - Structural Basis for Translation Mechanisms

  • Structure and function of the ribosome
  • Ensemble cryo-EM

Representative Publications

  • Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation. Demo G, Gamper HB, Loveland AB, Masuda I, Carbone CE, Svidritskiy E, Hou YM, Korostelev AA.Nat Commun. 2021 Jul 30;12(1):4644. doi: 10.1038/s41467-021-24911-1.PMID: 34330903 Read Publication
More Publications

In the News

  • PhD candidate Emily Sholi receives grant to study pathogens’ impact on ribosomes
    Dec 8, 2025

    PhD candidate Emily Sholi receives grant to study pathogens’ impact on ribosomes

    PhD candidate Emily Sholi has received an NIH fellowship to further her ribosome research, investigating how pathogens inhibit host ribosomes.

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  • UMass Chan scientists show ribosomes play unexpected role in blood vessel formation
    Jul 1, 2024

    UMass Chan scientists show ribosomes play unexpected role in blood vessel formation

    Research by Andrei Korostelev, PhD, and Anna Loveland, PhD, shows that the ribosome plays an unexpected role in the activation of angiogenin, allowing it to cleave transfer RNA, thereby halting protein production. These findings shed new light on angiogenin functioning and may have important implications for the design of cancer therapeutics and neurodegenerative disease treatments.  

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  • UMass Chan BRIDGE Fund invests nearly $2M in 13 faculty projects
    Aug 3, 2023

    UMass Chan BRIDGE Fund invests nearly $2M in 13 faculty projects

    The BRIDGE Fund supports critical research milestones for inventions and discoveries that have high potential to change the course of disease and continues to grow, increasing from approximately $1 million per year in 2019 to $3 million in 2024.

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  • Communicating science: Andrei Korostelev using structural biology to tackle antibiotic resistance
    May 3, 2022

    Communicating science: Andrei Korostelev using structural biology to tackle antibiotic resistance

    A recent survey of health care professionals showed nearly 60 percent of participants encountered patients whose infections didn’t respond to any antibiotic. Andrei Korostelev, PhD, says by studying the biology of bacterial cells, effective new antibiotics can be developed.

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