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Total: displaying 10 out of 15 results

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

Monday, November 24, 2025

Author(s): Melissa S Rotunno,Megan Fowler-Magaw,Jianjun Zhong,Kennedy O'Hara,Elenore A Wiggin,Debra Cameron,Karly Stallworth,James Bouley,Holly McEachern,Mina N Anadolu,Jeffrey A Nickerson,Andrew R Tapper,Susann...

Source: bioRxiv : the preprint server for biology
A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

Wednesday, August 27, 2025

Author(s): Asli Ertekin,Sharon T Noronha,Christable Darko,Francesca Massi,Sean P Ryder

Source: RNA (New York, N.Y.)
A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

Wednesday, June 04, 2025

Author(s): Asli Ertekin,Sharon T Noronha,Christable Darko,Francesca Massi,Sean P Ryder

Source: bioRxiv : the preprint server for biology
A Hydrophobic Core Stabilizes the Residual Structure in the RRM2 Intermediate State of the ALS-linked Protein TDP-43

Saturday, October 19, 2024

Author(s): Brian C Mackness,Brittany R Morgan,Laura M Deveau,Sagar V Kathuria,Jill A Zitzewitz,Francesca Massi

Source: Journal of molecular biology
Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity

Wednesday, September 25, 2024

Author(s): Asli Ertekin,Brittany R Morgan,Sean P Ryder,Francesca Massi

Source: Biochemistry
A hydrophobic core stabilizes the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43

Tuesday, June 25, 2024

Author(s): Brian C Mackness,Brittany R Morgan,Laura M Deveau,Sagar V Kathuria,Jill A Zitzewitz,Francesca Massi

Source: bioRxiv : the preprint server for biology
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Thursday, March 21, 2024

Author(s): Salome Funes,Jonathan Jung,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,None Shankaracharya,Matthew Unger,Karly Stallworth,Debra Cameron,Melissa S Rotunno,Pepper Dawes,Megan Fowler-Magaw,Pamela J K...

Source: Nature communications
A nematode model to evaluate microdeletion phenotype expression

Monday, November 13, 2023

Author(s): Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder

Source: G3 (Bethesda, Md.)
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

Monday, July 03, 2023

Author(s): Salome Funes,Del Hayden Gadd,Michelle Mosqueda,Jianjun Zhong,Jonathan Jung,None Shankaracharya,Matthew Unger,Debra Cameron,Pepper Dawes,Pamela J Keagle,Justin A McDonough,Sivakumar Boopathy,Miguel Sen...

Source: bioRxiv : the preprint server for biology
The Role of Substrate Mediated Allostery in the Catalytic Competency of the Bacterial Oligosaccharyltransferase PglB

Monday, October 04, 2021

Author(s): Brittany R Morgan,Francesca Massi

Source: Frontiers in molecular biosciences
ALS-linked PFN1 variants exhibit loss and gain of functions in the context of formin-induced actin polymerization

Wednesday, June 02, 2021

Author(s): Eric J Schmidt,Salome Funes,Jeanne E McKeon,Brittany R Morgan,Sivakumar Boopathy,Lauren C O'Connor,Osman Bilsel,Francesca Massi,Antoine Jégou,Daryl A Bosco

Source: Proceedings of the National Academy of Sciences of the United States of America
Analysis of Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

Friday, May 21, 2021

Author(s): Sean P Ryder,Brittany R Morgan,Peren Coskun,Katianna Antkowiak,Francesca Massi

Source: Evolutionary bioinformatics online
Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

Thursday, June 25, 2020

Author(s): Sean P Ryder,Brittany R Morgan,Francesca Massi

Source: bioRxiv : the preprint server for biology
A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5

Thursday, April 16, 2020

Author(s): Davide Tavella,Asli Ertekin,Hila Schaal,Sean P Ryder,Francesca Massi

Source: Biophysical journal
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein

Sunday, March 17, 2019

Author(s): Sujit Basak,R Paul Nobrega,Davide Tavella,Laura M Deveau,Nobuyasu Koga,Rie Tatsumi-Koga,David Baker,Francesca Massi,C Robert Matthews

Source: Proceedings of the National Academy of Sciences of the United States of America

In the News

Latest BMB news as reported by the UMass Chan Communications Office

Cynthia Fuhrmann recognized with Distinguished Service Award from National Postdoctoral Association

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UMass Chan awarded $800K to advance ALS research

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4D Nucleome Consortium produces detailed models of the 3D genome over time in cells

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Top story: UMass Chan celebrates naming of Paul J. DiMare Center

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PhD candidate Emily Sholi receives grant to study pathogens’ impact on ribosomes

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Chancellor Collins’ final Convocation address encourages optimism, determination

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Inspired by faculty mentor, MD/PhD candidate pursuing dermatology

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UMass Chan celebrates naming of Paul J. DiMare Center

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Kristen Matteson and Mary Munson selected for Executive Leadership in Academic Medicine Program for Women

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Morningside Graduate School of Biomedical Sciences honors students during annual awards ceremony

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Origen Biotechnology funds research at UMass Chan to advance gene therapy technology

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New research examines mechanisms of protein complex at basic cell biological level

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PhD student among first to join UMass Chan program focused on quantitative skills

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