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Kara Smith, MD, publication report from PubMed

Total: 20 results

  • The Formylation of N,N‑Dimethylcorroles

    Monday, October 20, 2025
    Author(s): Sara Nardis,Alessia Fata,Francesco Pizzoli,Greta Imbesi,Greta Petrella,Daniel O Cicero,Frank R Fronczek,Kevin M Smith,Roberto Paolesse
    Source: ACS omega
    The chemistry of N-alkylcorroles is almost unexplored, although it could represent a promising route for further tuning the properties of this porphyrinoid. Herein, we report our investigations on the β-formylation of N(21),N(22)-dimethyl-5,10,15-tritolylcorrole, showing how different regioisomers can be obtained by modifying the functionalization reaction sequence. β-Formyl-N(21),N(22)-dimethyl-5,10,15-tritolylcorrole shows unprecedented reactivity toward acetone in basic conditions, affording...

  • Surgical and Patient Factors Associated with Baseplate Failures After Reverse Shoulder Arthroplasty: A Study by the ASES Complications of RSA Multicenter Research Group

    Friday, October 10, 2025
    Author(s): ASES Complications of RSA Research Group,Adam Bowler,Evan A Glass,Jason Corban,Declan R Diestel,Miranda McDonald-Stahl,Calista S Stevens,Regan P Arnold,Himmat Sahi,Richard Puzzitiello,Daniel P Swanson,Michael A Moverman,Ryan Lohre,Kuhan A Mahendraraj,Kiet Le,Warren R Dunn,Dylan J Cannon,Hunter Carlson,Peter J Chabot,Charles Cogan,Matthew R Colatruglio,Lisa G M Friedman,Jaina A Gaudette,John Green,Lauren Grobaty,Michael Gutman,Jason C Ho,Keegan Hones,Ermyas Kahsai,Jacquelyn Kakalecik,Mitchell Kirkham,Michael A Kloby,Elliot N Konrade,Margaret C Knack,Tyler LaMonica,Amy Loveland,Joshua I Mathew,Emma Merrill,Albert D Mousad,Luke Myhre,Andrew Nahr,Jacob Nyfeler,Doug E Parsell,Midhat Patel,Marissa Pazik,Teja S Polisetty,Padmavathi Ponnuru,John Scanaliato,Arden Shen,Karch M Smith,Katherine A Sprengel,Ocean Thakar,Lacie Turnbull,Alayna Vaughan,John C Wheelwright,Anastasia Whitson,Anna B Williams,Tyler Williams,Joseph Abboud,April Armstrong,Luke Austin,Tyler Brolin,Vahid Entezari,Grant E Garrigues,Brian Grawe,Lawrence V Gulotta,Rhett Hobgood,John G Horneff,Joseph Iannotti,Jason E Hsu,Michael Khazzam,Joseph J King,Jacob M Kirsch,Jonathan C Levy,Anand Murthi,Surena Namdari,Gregory P Nicholson,Randall J Otto,Eric T Ricchetti,Robert Z Tashjian,Thomas Throckmorton,Thomas Wright,Andrew Jawa
    Source: Journal of shoulder and elbow surgery
    CONCLUSION: Revision surgery, bone grafting (especially allografts), and increased lateral offset were significantly associated with higher odds of baseplate failure after rTSA. Central screw fixation appears protective. Most failures were atraumatic, underscoring the importance of achieving stable bone ingrowth. These findings may inform surgical planning and patient counseling regarding factors associated with increased failure risk.

  • Ladder-Type Cu(II) Coordination Polymer with π-π Stacking of Planar Blatter Radical Ligands: Structural and Magnetic Characterization

    Monday, October 06, 2025
    Author(s): Hemant K Singh,Kayla M Smith,Jeremy M Rawson,Bruno Camargo,Ethan S Pollett,Oleksandr Hietsoi,Andrienne C Friedli,Piotr Kaszyński
    Source: Crystal growth & design
    The synthesis of two C(2)-pyridyl derivatives of the planar Blatter radical was developed by using the tris-(trimethylsilyl)-silane (TTMSS)-assisted cyclization of appropriate iodoarenes. These monodentate paramagnetic ligands were characterized by spectroscopic (UV-vis and electron paramagnetic resonance (EPR)) and electrochemical methods and reacted with (pdc)-Cu-(H(2)O)(3). A complex containing the 3-pyridyl group was characterized structurally, revealing novel polymeric Cu-O-Cu-O ladders...

  • Reported contributors to communication vulnerability for adult patients in critical care

    Saturday, September 13, 2025
    Author(s): Laura Istanboulian,Amy Freeman-Sanderson,Anthony Gilding,Praisy Rampogu,Kelly M Smith,Karen Soldatić
    Source: Intensive & critical care nursing
    CONCLUSIONS: This study presents patient, family, and healthcare provider reported contributors to patient communication vulnerability in the intensive care unit beyond patient-factors. Identifying socio-relational, environmental and structural related factors contributing to communication vulnerability provides multiple opportunities to improve patient communication practices and safety for adults in the intensive care unit.

  • Erratum: Invasive Neurostimulation During Pregnancy for Treatment of Epilepsy and Tourette Syndrome: Maternal and Fetal Outcomes

    Monday, August 11, 2025
    Author(s): Anhmai Vu,Aisha Abdulrazaq,Brian N Lundstrom,Lauren M Jackson,Jeffrey W Britton,William O Tatum,Cornelia Drees,Elizabeth A Coon,Linda M Szymanski,Gregory A Worrell,Kelsey M Smith
    Source: Neurology. Clinical practice
    [This corrects the article DOI: 10.1212/CPJ.0000000000200498.].

  • Relative Strength Variability Measures for Brain Structural Connectomes and Their Relationship With Cognitive Functioning

    Wednesday, August 06, 2025
    Author(s): Hon Wah Yeung,Colin R Buchanan,Joanna Moodie,Ian J Deary,Elliot M Tucker-Drob,Mark E Bastin,Heather C Whalley,Keith M Smith,Simon R Cox
    Source: Human brain mapping
    In this work, we propose a new class of graph measures for weighted connectivity information in the human brain based on node relative strengths: relative strength variability (RSV), measuring susceptibility to targeted attacks, and hierarchical RSV (hRSV), a first weighted statistical complexity measure for networks. Using six different network weights for structural connectomes from the UK Biobank, we conduct comprehensive analyses to explore relationships between the RSV and hRSV, and (i)...

  • Patient Perspectives on Artificial Intelligence in Health Care: Focus Group Study for Diagnostic Communication and Tool Implementation

    Thursday, July 24, 2025
    Author(s): Garrett Foresman,Joshua Biro,Alberta Tran,Kate MacRae,Sadaf Kazi,Laura Schubel,Adam Visconti,William Gallagher,Kelly M Smith,Traber Giardina,Helen Haskell,Kristen Miller
    Source: Journal of participatory medicine
    CONCLUSIONS: This study highlights the importance of incorporating patient perspectives in the design and implementation of AI tools in health care. Transparency, human oversight, clear communication, and data privacy are crucial for patient trust and acceptance of AI in diagnostic processes. These findings inform strategies for individual clinicians, health care organizations, and policy makers to ensure responsible and patient-centered AI deployment in health care.

  • Variable angle locking mesh plate for fixation of comminuted greater tuberosity fractures

    Wednesday, July 23, 2025
    Author(s): Michael E Hachadorian,Garrett K Berger,Karch M Smith,William T Kent
    Source: JSES reviews, reports, and techniques
    No abstract

  • Induction of Human Pruriceptors from Pluripotent Stem Cells via Transcription Factors

    Tuesday, July 15, 2025
    Author(s): Hisato Iriki,Ruiqi Hu,Xu Li,Erdene Baljinnyam,Carina Habich,Ichiro Imanishi,Loan Miller,Kavya Chegireddy,Laraib Iqbal Malik,Daniel Yassky,Aaron Ver Heul,Kathleen M Smith,Eric R Goedken,Peter Reinhardt,Brian S Kim,Samuele G Marro
    Source: bioRxiv : the preprint server for biology
    Pruriception is crucial for defense against external stimuli but can lead to chronic pruritus, a debilitating condition affecting millions worldwide. Our understanding of the cellular and molecular mechanisms behind the sensation of itch has been hindered by the lack of functional human models. Here, we address this limitation by developing a protocol to generate induced pruriceptors (iPruriceptors) from human pluripotent stem cells (hPSCs). We compared two differentiation approaches: a direct...

  • Diagnostic Accuracy of Point-of-Care Ultrasound for Acute Pediatric Ankle Injuries

    Wednesday, July 09, 2025
    Author(s): Kathleen M Smith,Elise Zimmerman,Zola Trotter,Shannon Wai
    Source: Pediatric emergency care
    CONCLUSIONS: POCUS alone or combined with OAR is an inadequate screening tool to detect pediatric ankle fractures.

  • Most Nursing Home Social Services Directors Express Interest in Training on Discrimination Based Upon Sexual Orientation and Gender Identity

    Thursday, June 26, 2025
    Author(s): Nadia Sabbagh Steinberg,Kara A Carter,Kevin M Smith,Mercedes Bern-Klug
    Source: Journal of gerontological social work
    This study explored nursing home social services directors' interest in receiving training related to discrimination based on sexual orientation and gender identity. Nationally representative data from the National Nursing Home Social Services Directors Survey of 2019 were used. Two-thirds of respondents reported moderate or strong interest in discrimination training. The subgroup most interested in this training topic were nonwhite, social work-educated men, not residing in the Midwest. While...

  • Invasive Neurostimulation During Pregnancy for Treatment of Epilepsy and Tourette Syndrome: Maternal and Fetal Outcomes

    Monday, June 16, 2025
    Author(s): Anhmai Vu,Aisha Abdulrazaq,Brian Lundstrom,Lauren M Jackson,Jeffrey W Britton,William O Tatum,Cornelia Drees,Elizabeth A Coon,Linda M Szymanski,Gregory A Worrell,Kelsey M Smith
    Source: Neurology. Clinical practice
    BACKGROUND AND OBJECTIVES: Invasive neurostimulation is rapidly becoming an established option for treatment of neurologic disorders, particularly those that are refractory to pharmacologic treatment. However, there is limited information on the use of neuromodulation during pregnancy. This study explores the safety and clinical outcomes of invasive neuromodulation-specifically vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS)-in pregnant patients...

  • Improving the Quality of Family Engagement in the Intensive Care Unit Through Essential Care Partner Programs

    Monday, June 02, 2025
    Author(s): Laura Istanboulian,Kelly M Smith,Karen Soldatić
    Source: Journal of nursing care quality
    No abstract

  • Use of ChatGPT for Urinary Symptom Management Among People With Spinal Cord Injury or Disease: Qualitative Study

    Thursday, May 29, 2025
    Author(s): Bat-Zion Hose,Amanda K Rounds,Ishaan Nandwani,Deanna-Nicole Busog,Traber Davis Giardina,Helen Haskell,Kelly M Smith,Kristen E Miller
    Source: JMIR rehabilitation and assistive technologies
    CONCLUSIONS: ChatGPT is a promising tool for symptom assessment and managing chronic conditions such as urinary symptoms in individuals with SCI/D. While ChatGPT enhances accessibility to health information, further research is needed to improve its transparency and integration with personalized health data to be a more usable tool in making informed health decisions.

  • Guidelines for the Diagnosis and Clinical Management of Cavernous Malformations of the Brain and Spinal Cord: Consensus Recommendations Based on a Systematic Literature Review by the Alliance to Cure Cavernous Malformation Clinical Advisory Board Experts Panel

    Wednesday, May 21, 2025
    Author(s): Amy L Akers,John Albanese,Roberto J Alcazar-Felix,Rustam Al-Shahi Salman,Issam A Awad,Edward S Connolly,Amy Danehy,Kelly D Flemming,Errol Gordon,Stephanie Hage,Helen Kim,Giuseppe Lanzino,Cornelia H Lee,Paul C McCormick,Marc C Mabray,Douglas A Marchuk,Edward Smith,Kelsey M Smith,Siddharth Srivastava,J Michael Taylor,Sudhakar Vadivelu
    Source: Neurosurgery
    CONCLUSION: Current evidence supports prior and new recommendations for the management of CMs, but many reflect moderate classes and low levels, mandating further research to better inform clinical practice.

  • Extending care beyond the clinic: integrating patient-reported outcomes in chronic pain management through human factors engineering

    Thursday, May 08, 2025
    Author(s): Sadaf Kazi,Robin Littlejohn,Kelly M Smith,Deanna-Nicole Busog,Joseph Blumenthal,Shrey Mathur,Zach McGill,Doug DeBold,Aaron Zachary Hettinger,Kristen E Miller
    Source: Frontiers in health services
    CONCLUSIONS: This project leveraged a multi-method approach based in human factors and UCD to develop the TAPR-CPM app. Engaging with a diverse set of stakeholders including patients, caregivers, primary care providers, pain specialists, and health information technology developers was critical to develop a user-friendly experience with accessible technology to support patient engagement and provider decision-making.

  • Constraints on Local Primordial Non-Gaussianity with 3D Velocity Reconstruction from the Kinetic Sunyaev-Zeldovich Effect

    Friday, May 02, 2025
    Author(s): Alex Laguë,Mathew S Madhavacheril,Kendrick M Smith,Simone Ferraro,Emmanuel Schaan
    Source: Physical review letters
    The cosmic velocity field is an unbiased probe of the total matter distribution but is challenging to measure directly at intermediate and high redshifts. The large-scale velocity field imprints a signal in the cosmic microwave background (CMB) through the kinetic Sunyaev-Zeldovich (kSZ) effect. We perform the first 3D reconstruction of the large-scale velocity field from the kSZ effect by applying a quadratic estimator to CMB temperature maps and the 3D positions of galaxies. We do so by...

  • Implant-Positioning and Patient Factors Associated with Acromial and Scapular Spine Fractures After Reverse Shoulder Arthroplasty: A Study by the ASES Complications of RSA Multicenter Research Group

    Wednesday, April 30, 2025
    Author(s): Michael A Moverman,Richard N Puzzitiello,Evan A Glass,Daniel P Swanson,Kristian Efremov,Ryan Lohre,Adam R Bowler,Kuhan A Mahendraraj,Kiet Le,Warren R Dunn,Dylan J Cannon,Lisa G M Friedman,Jaina A Gaudette,John Green,Lauren Grobaty,Michael Gutman,Jaquelyn Kakalecik,Michael A Kloby,Elliot N Konrade,Margaret C Knack,Amy Loveland,Joshua I Mathew,Luke Myhre,Jacob Nyfeler,Doug E Parsell,Marissa Pazik,Teja S Polisetty,Padmavathi Ponnuru,Karch M Smith,Katherine A Sprengel,Ocean Thakar,Lacie Turnbull,Alayna Vaughan,John C Wheelwright,Joseph Abboud,April Armstrong,Luke Austin,Tyler Brolin,Vahid Entezari,Grant E Garrigues,Brian Grawe,Lawrence V Gulotta,Rhett Hobgood,John G Horneff,Jason E Hsu,Joseph Iannotti,Michael Khazzam,Joseph J King,Jacob M Kirsch,Jonathan C Levy,Anand Murthi,Surena Namdari,Gregory P Nicholson,Randall J Otto,Eric T Ricchetti,Robert Tashjian,Thomas Throckmorton,Thomas Wright,Andrew Jawa,ASES Complications of RSA Multicenter Research Group
    Source: The Journal of bone and joint surgery. American volume
    CONCLUSIONS: Patient factors associated with poor bone density and rotator cuff deficiency appear to be the strongest predictors of ASFs and SSFs after RSA. Final implant positioning, to a lesser degree, may also affect ASF and SSF prevalence in at-risk patients, as increased humeral lateralization was found to be associated with lower fracture rates whereas excessive glenoid-sided and global lateralization were associated with higher fracture rates.

  • Disparities in Initial Antihypertensive Intensity by Sex, Race and Ethnicity in Newly Treated Patients With Hypertension

    Tuesday, April 22, 2025
    Author(s): Shailina Keshwani,Kayla M Smith,Almut G Winterstein,Matthew J Gurka,Marta G Walsh,Anne Libby,William Hogan,Carl J Pepine,Rhonda M Cooper-DeHoff,Steven M Smith
    Source: American journal of hypertension
    CONCLUSIONS: We observed disparities in treatment intensity by sex and race that were not explained by differences in clinical factors. There was sex-based variation in practice patterns, and Black individuals received more intensive initial antihypertensive therapy than White individuals.

  • AI-driven predictive biomarker discovery with contrastive learning to improve clinical trial outcomes

    Friday, April 18, 2025
    Author(s): Gustavo Arango-Argoty,Damian E Bikiel,Gerald J Sun,Elly Kipkogei,Kaitlin M Smith,Sebastian Carrasco Pro,Elizabeth Y Choe,Etai Jacob
    Source: Cancer cell
    Modern clinical trials can capture tens of thousands of clinicogenomic measurements per individual. Discovering predictive biomarkers, as opposed to prognostic markers, remains challenging. To address this, we present a neural network framework based on contrastive learning-the Predictive Biomarker Modeling Framework (PBMF)-that explores potential predictive biomarkers in an automated, systematic, and unbiased manner. Applied retrospectively to real clinicogenomic datasets, particularly for...