Deterioration of mitochondria and metabolism is a common component of numerous diseases such as cancer and neurodegeneration as well as the aging process. The Haynes Lab focuses on mechanisms utilized by cells to maintain or recover mitochondrial activity and cellular health in a number of physiologic and pathologic scenarios focusing on a stress response known as the mitochondrial UPR.
- Lin YF, Haynes CM. (2016) Metabolism and the UPRmt. Molecular Cell. Mar 3:61(5): 677-682.
- Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM. (2016) Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature. May 2:533(7603): 416-419.
- Nargund AN*, Pellegrino MW*, Fiorese CJ, Baker BM, Haynes CM. (2012) Mitochondrial import of ATFS-1 regulates mitochondrial UPR activation. Science. Aug 3;337(6094): 587-90.
- Nargund AN, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM. (2015) Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPRmt. Molecular Cell. April 2;58(1):123-33.