Aneuploidy, which represents a cellular state of having an abnormal number of chromosomes, is a hallmark of cancer. The degree of aneuploidy significantly correlates with tumor aggressiveness and poor clinical prognosis. The Torres lab uses yeast as a model organism to reveal how conserved cellular processes are affected by aneuploidy. These studies will significantly improve our understanding of the role of aneuploidy in tumor biology.

• Torres et al. (2007). Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science. 317, 916-924.
• Torres et al. (2010). Identification of aneuploidy-tolerating mutations. Cell. 143, 71-83.