The Lewis lab is interrogating the mechanisms that underlie the progression and metastasis of hepatocellular carcinoma and pancreatic adenocarcinomas. Using a combination of cell culture models, molecular biology approaches, and in vivo modeling, the Lewis lab is characterizing the roles of novel factors involved in tumor dissemination. A current area of focus is the molecular dissection of a novel KLF6-VAV3-RAC1 signaling axis that regulates hepatocellular carcinoma invasion and metastasis.
Chen et al (2009) Differential Roles of Insulin-like Growth Factor Receptor- and Insulin Receptor-Mediated Signaling in the Phenotypes of Hepatocellular Carcinoma Cells. Neoplasia 11(9): 835-45.
Chen Y-W et al. (2013) p16 stimulates CDC42-dependent migration of hepatocellular carcinoma cells. PLOS One. 10.1371/journal.pone.0069389.
Ahronian et al. (2015) The p53R172H mutant does not enhance hepatocellular carcinoma development and progression. PLOS One.Apr 17;10(4):e0123816.