The Kim lab investigates how various metabolic pathways, such as amino acid biosynthesis pathways, in a tumor cell relative to normal tissues. The lab aims to elucidate advantages these metabolic alterations can play in the growth and progression of tumors, and how these changes can be exploited to selective target cancer cells, such as selectively inducing the accumulation of toxic metabolites to poison cancer cells within the tumor.

• Kim et al. (2015) SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature, 520(7547):363-367.
• Carlisle et al. (2020)Selenium detoxification is required for cancer-cell survival. Nature Metabolism, 2(7):603-611.
• Lee et al. (2020) Endogenous toxic metabolites and implications in cancer therapy. Oncogene, 39(35):5709-5720.