The ordering of cell cycle events is important to ensure that the genome is fully replicated before chromosomes segregate and cells divide. To achieve this ordering, many cell cycle-regulatory proteins are expressed exclusively when their functions are needed. The Benanti lab is interested in understanding why cyclical expression of key regulatory proteins is important for maintaining a stable genome. In addition, they are investigating how cell cycle-regulation of chromatin proteins helps to coordinate the condensation of chromosomes with their segregation during mitosis.

• Benanti et al. (2009) Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Molecular Cell, 33(5):581-90 
• Doughty et al. (2016) Levels of Ycg1 limit condensin function during the cell  cycle. PLos Genetics, Jul 27;12(7):e1006216.