The Wolfe Lab focuses on multiple aspects of gene expression, including transcriptional and post-transcriptional control.   They are also interested in developing new tools for targeted gene regulation.  In addition, the Wolfe Lab is part of the Innate Immune Gene Regulatory Project, a collaborative effort to understand the regulatory pathways that underpin the response of Dendritic cells to pathogens.  Regarding post-transcriptional control of gene expression, they are focused on understanding the role of miR-375 in pancreatic endocrine cell development using zebrafish as a model.  

• Zhu L et al.  (2011) FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system.  Nucleic Acids Res. 39(Database issue):D111-7. 
• Enuameh et al (2013) Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants. Genome Res. 23(6):928-40.   
• Kearns et al. (2014) Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells.  Development, 141(1):219-23.