The Wolfe Lab focuses on multiple aspects of gene expression, including transcriptional and post-transcriptional control. They are also interested in developing new tools for targeted gene regulation. In addition, the Wolfe Lab is part of the Innate Immune Gene Regulatory Project, a collaborative effort to understand the regulatory pathways that underpin the response of Dendritic cells to pathogens. Regarding post-transcriptional control of gene expression, they are focused on understanding the role of miR-375 in pancreatic endocrine cell development using zebrafish as a model.