Mao Lab

The Mao laboratory studies transcriptional regulation mediated by several signaling pathways (Hedgehog, Wnt and Hippo) in tissue stem cells, progenitors, and transformed cancer cells. They use RNAseq, ChIPseq and Bioinformatics to investigate how tissue- or cancer-specific transcriptional output of these pathways is achieved. 

  • Rajurkar et al. (2012) The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. PNAS.  109(17): E1038-47.
  • Wang et al. (2013) TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBP function. Molecular Cell 51(2):211-25.