Bach Lab

One of the main goals of the research carried out in the Bach lab is to understand mechanisms controlling gene expression during mammalian embryogenesis. The research investigates how the dynamic regulation of transcription factor activity orchestrates cell fate decisions during development and how disturbances can lead to human disease. More recently, the lab also studies how female cells inactivate one of their two X chromosomes in a process called X-chromosome inactivation (XCI), a form of epigenetic gene silencing. 

  • Güngör et al., 2007 Proteasomal selection of multiprotein complexes recruited by LIM-HD transcription factors. Proc Natl Acad Sci USA 104, 15000-5
  • Shin et al., 2010. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature 467, 977-81
  • Shin et al., 2014. RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature 511, 86-9