Genes encoding chromatin regulatory proteins encompass some of the most frequent targets of mutation in cancer. However, the contributions of these mutations to oncogenesis are not easily understood, due to the fact that most chromatin regulators regulate expression of thousands of genes, in addition to roles in DNA replication and repair. The Fazzio lab is examining the roles of several chromatin remodeling complexes that have known tumor-suppressive roles, to better understand how their loss leads to cancer.