Aberrant activation of gene transcription by the estrogen receptor (ER) plays a crucial role in inducing human breast tumors. Because LIM cofactors RLIM and CLIM regulate the transcriptional activity of ER in breast cancer cells, the Bach lab studies functions of these cofactors in mammary glands and during the formation of breast cancer.

• Johnsen et al. (2009) Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res 69, 128-36
• Jiao et al. (2012) Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell 149, 630-41
• Jiao et al. (2013) Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Mol Biol Cell 24, 3085-96