Tissue homeostasis requires a careful balance between cellular proliferation, differentiation, and cell death.  Research in the Kelliher Lab focuses on the role of RIP kinases and how they regulate cell death, particularly in the context of inflammation.  For this purpose, they rely on the mouse as a model system to interrogate the pathways that control inflammation.  In particular, the Kelliher Lab has developed conditional and kinase inactive knock-in alleles of RIPK1 that they have used to reveal novel physiologic requirements for RIPK1 in tissue homeostasis.

• Dannappel et al. (2014) RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature, 513(7516):90-4
• Roderick et al. Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. (2014) Proc Natl Acad Sci U S A. 111(40):14436-41