Deterioration of mitochondria is a common component of numerous diseases as well as the aging process. The Haynes Lab focuses on mechanisms utilized by cells to maintain or recover mitochondrial activity and cellular health in a number of physiologic and pathologic scenarios focusing on a stress response known as the mitochondrial UPR.

• Nargund AN*, Pellegrino MW*, Fiorese CJ, Baker BM, Haynes CM. (2012) Mitochondrial import of ATFS-1 regulates mitochondrial UPR activation. Science. Aug 3;337(6094): 587-90.
• Fiorese CJ*, Schulz AM*, Lin YF, Rosin N, Pellegrino MW, Haynes CM. (2016) The transcription factor ATF5 mediates a mammalian mitochondrial UPR. Current Biology. 2016.
• Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM. (2016) Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature. May 2:533(7603): 416-419.
• Lamech, LT, Haynes CM. (2015) The unpredictability of prolonged activation of stress response pathways. Journal of Cell Biology. June 22:209(6): 781-87.