Our lab studies how autophagy (self eating) is regulated and functions in complex multi-cellular organisms.  Autophagy is used to clear materials from cells, and helps to maintain cell health.  Researchers in the laboratory screen for novel mechanisms that control autophagy, and determine how autophagy functions to promote cell health and cell death in different cells and tissues within animals.

• Berry DL, Baehrecke EH. (2007) Growth arrest and autophagy are required for salivary   gland cell degradation in Drosophila. Cell. 2007 Dec 14;131(6):1137-48. PubMed PMID: 18083103; PubMed Central PMCID: PMC2180345.
• McPhee CK, Logan MA, Freeman MR, Baehrecke EH. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 2010 Jun 24;465(7301):1093-6. PubMed PMID: 20577216; PubMed Central PMCID: PMC2892814.
• Chang TK, Shravage BV, Hayes SD, Powers CM, Simin RT, Wade Harper J, Baehrecke EH. Uba1 functions in Atg7- and Atg3-independent autophagy. Nat Cell Biol. 2013 Sep;15(9):1067-78. PubMed PMID: 23873149; PubMed Central PMCID: PMC3762904.
• Nelson C, Ambros V, Baehrecke EH. miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell. 2014 Nov 6;56(3):376-88. PubMed PMID: 25306920; PubMed Central PMCID: PMC4252298.
• Lin L, Rodrigues FSLM, Kary C, Contet A, Logan M, Baxter R, Wood W and Baehrecke EH (2017) Complement-related regulates autophagy in neighboring cells. Cell 2017 Jun 29;170(1):158-171. PMID: 2866617 PubMed Central PMCID: PMC5533186.
• Velentzas PD, Zhang L, Das G, Chang TK, Nelson C, Kobertz WR, Baehrecke EH. The proton-coupled monocarboxylate transporter Hermes is necessary for autophagy during cell death. Dev Cell. 2018 Oct 9: 47:281-293. PMID: 30318245 PubMed Central PMCID: in progress.