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Scot A. Wolfe, PhD

Research Focus - Therapeutic Genome Editing Systems

Application of novel Cas9/Cas12a-based genome editing systems
Use of therapeutic genome editing for β-hemoglobinopathies and other hematopoietic disorders
Use of therapeutic genome editing for muscular dystrophies
Development of delivery approaches for somatic cell genome editing
Development of artificial zinc finger-based transcriptional regulators

Iyer S, Suresh S, Guo D, et al. Precise therapeutic gene correction by a simple nuclease-induced double-strand break. Nature. 2019;568(7753):561-565.

Getting Results…

UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

UMass Chan supports translational research from faculty with internal funding mechanism.

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Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium

Six UMass Medical School scientists are among the members of the National Institutes of Health’s Somatic Cell Genome Editing Consortium to publish a paper in Nature outlining the program’s goals.

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