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About

Located in Worcester, Massachusetts, the UMass Cancer Center is committed to providing exceptional patient care, conducting cutting-edge research at the highest level, offering excellence in education and training, and serving as an educational resource and advocate for the Central Massachusetts community.
Patients
Patients

Expert Cancer Care in Central Massachusetts

We offer comprehensive cancer care for all childhood and adult cancers, combining state-of-the-art treatments with compassionate support for patients and their families.
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Research
Research

Cutting-Edge Cancer Research

We carry out front-line research in basic, translational, clinical and population-based discovery to find newer, better methods for the prevention, detection, diagnosis, and treatment of cancer.
Education
Education

World Class Medical and Scientific Education

The UMass Cancer Center is dedicated to training the next generation of cancer researchers, clinicians and physician-scientists.
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Additional Resources

Scot A. Wolfe, PhD

Professor, Department of Molecular, Cell and Cancer Biology, UMass Chan Medical School

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Scot A. Wolfe, PhD

Research Focus - Therapeutic Genome Editing Systems

Application of novel Cas9/Cas12a-based genome editing systems
Use of therapeutic genome editing for β-hemoglobinopathies and other hematopoietic disorders
Use of therapeutic genome editing for muscular dystrophies
Development of delivery approaches for somatic cell genome editing
Development of artificial zinc finger-based transcriptional regulators

Representative Publication

Iyer S, Suresh S, Guo D, et al. Precise therapeutic gene correction by a simple nuclease-induced double-strand break. Nature. 2019;568(7753):561-565.

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In the News

Getting Results…

Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium

Six UMass Medical School scientists are among the members of the National Institutes of Health’s Somatic Cell Genome Editing Consortium to publish a paper in Nature outlining the program’s goals.

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